BIOREJ - Filling and modeling solution for the dermal matrix based on hyaluronic acid - Mesorga

Hyaluronic acid (HA) is a polysaccharide with extraordinary properties. It is composed of disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine, joined by glycosidic bonds. It is part of the extracellular matrix (ECM) and is present in different parts of the body, such as connective tissue, skin, umbilical cord, synovial fluid and other tissues. HA is synthesized on the cell membrane and released into the extracellular space. This process is controlled by membrane proteins called hyaluronic acid synthetase, which use the UDP nucleotide to build the HA chain until it reaches a molecular weight of about 4 million daltons.

CD44 is a membrane protein that binds hyaluronic acid (HA) significantly and is widely expressed in several cell types, especially in macrophages.

The interaction between HA and CD44 plays an important role in the development and resolution of inflammation,
in the activation and recruitment of T cells, as well as in tumor growth and metastasis. HA also has the ability to influence cell proliferation, differentiation and migration.

Based on this knowledge, the Mesorga company developed the class 3 sterile injectable medical device called Biorej.

This device is based on biostimulation through
the activation of CD44 receptors. In particular, the activation of CD44 on fibroblasts induces the formation of reticular collagen, which is typical of young skin, thus allowing effective dermal regeneration if stimulated correctly.

Mesorga® Biorej is suitable for all skin types and can be used in all areas of the face and body that need to be revitalized and biostimulated through an injection of small doses into the superficial layer of the dermis.

We recommend, with protocols that can be customized by the doctor depending on age or skin type, cycles of at least three treatments for the first month and
at least two for the second month, followed by a 30-day maintenance period.